Recombinant Human RICTOR protein (ab112435)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MAAIGRGRSLKNLRVRGRNDSGEENVPLDLTREPSDNLREILQNVARLQG VSNMRKLGHLNNFTKLLCDIGHSEEKLGFHYEDIIICLRLALLNEAKE
    • 分子量
      36 kDa including tags
    • 領域
      1 to 98

特性

Our Abpromise guarantee covers the use of ab112435 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

関連情報

  • 別名
    • AVO3
    • AVO3 homolog
    • DKFZp686B11164
    • hAVO3
    • KIAA1999
    • Likely ortholog of mouse TORC2 specific protein AVO3 (S. cerevisiae)
    • mAVO3
    • MGC39830
    • PIA
    • Pianissimo
    • Rapamycin insensitive companion of mTOR
    • Rapamycin-insensitive companion of mTOR
    • Rictor
    • RICTR
    • RICTR_HUMAN
    • RPTOR independent companion of MTOR complex 2
    • TORC2 specific protein AVO3
    see all
  • 機能
    Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
  • 配列類似性
    Belongs to the RICTOR family.
  • 翻訳後修飾
    Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.
  • Information by UniProt

画像

  • ab112435 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

参考文献

ab112435 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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