Recombinant Human Retinoid X Receptor alpha protein (ab48737)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MLGLNGVLKV PAHPSGNMAS FTKHICAICG DRSSGKHYGV YSCEGCKGFF KRTVRKDLTY TCRDNKDCLI DKRQRNRCQY CRYQKCLAMG MKREAVQEER QRGKDRNENE VESTSSANE
    • 領域111 to 228

特性

Our Abpromise guarantee covers the use of ab48737 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    The Retinoid X Receptor alpha protein (111-228aa) was over expressed in E.coli and purified by using conventional column chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1M Sodium chloride, 5mM Beta mercaptoethanol, 20mM Tris HCl, pH 7.5

関連情報

  • 別名
    • FLJ00280
    • FLJ00318
    • FLJ16020
    • FLJ16733
    • MGC102720
    • NR2B1
    • Nuclear receptor subfamily 2 group B member 1
    • OTTHUMP00000022510
    • Retinoic acid receptor RXR alpha
    • Retinoic acid receptor RXR-alpha
    • Retinoid X nuclear receptor alpha
    • Retinoid X receptor alpha
    • RXR alpha1
    • Rxra
    • RXRA_HUMAN
    • RXRalpha1
    see all
  • 機能Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.
  • 組織特異性Highly expressed in liver, also found in lung, kidney and heart.
  • 配列類似性Belongs to the nuclear hormone receptor family. NR2 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • ドメインComposed of three domains: a modulating N-terminal domain (AF1 domain), a DNA-binding domain and a C-terminal ligand-binding domain (AF2 domain).
  • 翻訳後修飾Phosphorylated on serine and threonine residues mainly in the N-terminal modulating domain. Constiutively phosphorylated on Ser-21 in the presence or absence of ligand. Under stress conditions, hyperphosphorylated by activated JNK on Ser-56, Ser-70, Thr-82 and Ser-260 (By similarity). Phosphorylated on Ser-27, in vitro, by PKA. This phosphorylation is required for repression of cAMP-mediated transcriptional activity of RARA.
    Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant Human Retinoid X Receptor alpha protein 画像

  • 14% SDS-PAGE gel loaded with recombinant human Retinoid X Receptor alpha protein.

Recombinant Human Retinoid X Receptor alpha protein (ab48737) 使用論文

ab48737 has not yet been referenced specifically in any publications.

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