製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MRGSHHHHHH GMASHMEEPQ RELPSARIRC PKGSKAYGSH CYALFLSPKS WTDADLACQK RPSGNLVSVL SGAEGSFVSS LVKSIGNSYS YVWIGLHDPT QGTEPNGEGW EWSSSDVMNY FAWERNPSTI SSPGHCASLS RSTAFLRWKD YNCNVRLPYV CKFTD
    • 分子量18 kDa
    • 領域27 to 175
    • 配列の追加情報The Recombinant Human REG3A protein is produced with N-terminal fusion of His Tag. The REG3A His -Tagged Fusion Protein is an 18.4 kDa protein containing 149 amino acid residues

特性

Our Abpromise guarantee covers the use of ab73486 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    ELISA

  • 精製度> 95 % SDS-PAGE.
    ab73486 is purified by a one-step procedure using affinity Ni-NTA chromatography.
  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 0.05M Acetate buffer, pH4

  • 再構成Add 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10µg/ml. In higher concentrations the solubility of this antigen is limited.

関連情報

  • 別名
    • FLJ18565
    • Hepatocarcinoma intestine pancreas
    • Hepatointestinal pancreatic protein
    • HIP
    • HIP/PAP
    • Human proislet peptide
    • INGAP
    • Pancreatic beta cell growth factor
    • Pancreatitis associated protein
    • Pancreatitis associated protein 1
    • Pancreatitis-associated protein 1
    • PAP
    • PAP H
    • PAP homologous protein
    • PAP1
    • PBCGF
    • Proliferation inducing protein 34
    • Proliferation inducing protein 42
    • REG III
    • Reg III alpha
    • Reg III-alpha
    • REG-3-alpha
    • REG3
    • Reg3a
    • REG3A_HUMAN
    • Regenerating islet derived 3 alpha
    • Regenerating islet derived protein 3 alpha precursor
    • Regenerating islet-derived protein 3-alpha 15 kDa form
    • Regenerating islet-derived protein III-alpha
    see all
  • 機能Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway.
  • 組織特異性Highly expressed in epidermal keratinocytes of psoriasis patients (at protein level). Constitutively expressed in intestine. Low expression is found in healthy pancreas. Overexpressed during the acute phase of pancreatitis and in some patients with chronic pancreatitis.
  • 配列類似性Contains 1 C-type lectin domain.
  • ドメインThe EPN motif is essential for recognition of the peptidoglycan carbohydrate backbone and for efficient bacterial killing with Glu-114 playing a key role in peptidoglycan binding and bactericidal activity.
  • 翻訳後修飾Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity.
  • 細胞内局在Secreted. Found in the apical region of pancreatic acinar cells.
  • Information by UniProt

Recombinant Human Reg3a protein (ab73486) 使用論文

This product has been referenced in:
  • Cui W  et al. Overexpression of Reg3alpha increases cell growth and the levels of cyclin D1 and CDK4 in insulinoma cells. Growth Factors 27:195-202 (2009). WB . Read more (PubMed: 19343564) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"