製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q96NR8
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MGSHM SIRAFAEGFL AEEKQLHILI NNAGVMMCPY SKTADGFETH LGVNHLGHFL LTYLLLERLK VSAPARVVNV SSVAHHIGKI PFHDLQSEKR YSRGFAYCHS KLANVLFTRE LAKRLQGTGV TTYAVHPGVV RSELVRHSSL LCLLWRLFSP FVKTAREGAQ TSLHCALAEG LEPLSGKYFS GKVVV ITGANTGIGK ETARELASRG ARVYIACRDV LKGESAASEI RVDTKNSQVL VRKLDLSDTK DCKRTWVSPR ARNNKTAERL WNVSCELLGI RWE
    • 分子量34 kDa including tags
    • 領域39 to 316
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab119458 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab119458 was purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 1.17% Sodium chloride, 0.03% DTT, 40% Glycerol

関連情報

  • 別名
    • All trans and 9 cis retinol dehydrogenase
    • All-trans and 9-cis retinol dehydrogenase
    • LCA 3
    • LCA13
    • LCA3
    • RDH 12
    • RDH12
    • RDH12_HUMAN
    • Retinol dehydrogenase 12
    • Retinol dehydrogenase 12 (all trans/9 cis/11 cis)
    • Retinol dehydrogenase 12 all trans and 9 cis
    • RP53
    • SDR7C2
    • Short chain dehydrogenase/reductase family 7C member 2
    see all
  • 機能Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments.
  • 組織特異性Widely expressed, mostly in eye, kidney, brain, skeletal msucle and stomach.
  • 関連疾患Defects in RDH12 are the cause of Leber congenital amaurosis type 13 (LCA13) [MIM:612712]. LCA designates a clinically and genetically heterogeneous group of childhood retinal degenerations, generally inherited in an autosomal recessive manner. Affected infants have little or no retinal photoreceptor function as tested by electroretinography. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
    Defects in RDH12 are the cause of retinitis pigmentosa type 53 (RP53) [MIM:612712]. RP53 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 配列類似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • Information by UniProt

Recombinant Human RDH12 protein 画像

  • 15% SDS-PAGE showing ab119458 at approximately 33.5kDa (3µg).

Recombinant Human RDH12 protein (ab119458) 使用論文

ab119458 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab119458.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"