製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWL PDVTRPEGKDF SIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHY DSEKGEFGGFGSVSGKIEIEIKIN HEGEVNRARYMPQNPCIIATKTPS SDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGL SWNPNLSGHLL SASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFG SVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATG SADKTVALWDLRN LKLKLHSFESHKDEIFQVQWSPHNETILASSGTDR RLNVWDLSKIGEEQSPEDAEDGPPEL LFIHGGHTAKISDFSWNPNEPW VICSVSEDNIMQVWQMAENIYN
    • 領域
      1 to 410

特性

Our Abpromise guarantee covers the use of ab93983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態
    Lyophilised
  • 備考
    Protein Identity confirmed by Mass Spectrometry (MS/MS) (acquired on initial reference batch)
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at 4°C prior to reconstitution. Store at -80°C.

    Preservative: None
    Constituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5

  • 再構成
    Reconstitute with 77 µl aqua dest.

関連情報

  • 別名
    • CAF I p48
    • CAF-1 subunit C
    • CAF-I 48 kDa subunit
    • CAF-I p48
    • Chromatin assembly factor 1 subunit C
    • Chromatin assembly factor I p48 subunit
    • Chromatin assembly factor/CAF 1 p48 subunit
    • Histone-binding protein RBBP4
    • MSI1 protein homolog
    • Nucleosome-remodeling factor subunit RBAP48
    • NURF55
    • RB binding protein 4 chromatin remodeling factor
    • RbAp 48
    • RBAP48
    • RBBP-4
    • RBBP4
    • RBBP4_HUMAN
    • Retinoblastoma binding protein 4
    • Retinoblastoma binding protein p48
    • Retinoblastoma-binding protein 4
    • Retinoblastoma-binding protein p48
    see all
  • 機能
    Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
  • 配列類似性
    Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
    Contains 6 WD repeats.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

画像

  • The image shows an electrophoretic assay performed using an Agilent 5100 ALP. In some images coloured control bands can be seen at 15 kDa (green) and/or 240 kDa (purple). The protein-specific band is blue.

参考文献

ab93983 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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