製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P20936-2
    • 生物種Human
    • 配列MKGWYHGKLDRTIAEERLRQAGKSGSYLIRESDRRPGSFVLSFLSQMNVV NHFRIIAMCGDYYIGGRRFSSLSDLIGYYSHVSCLLKGEKLLYPVAPPEP VEDRRRVRAILPYTKVPDTDEISFLKGDMFIVHNELEDGWMWVTNLRTDE QGLIVEDLVEEVGREEDPHEGKIWFHGKISKQEAYNLLMTVGQVCSFLVR PSDNTPGDYSLYFRTNENIQRFKICPTPNNQFMMGGRYYNSIGDIIDHYR KEQIVEGYYLKEPVPMQDQEQVLNDTVDGKEIYNTIRRKTKDAFYKNIVK KGYLLKKGKGKRWKNLYFILEGSDAQLIYFESEKRATKPKGLIDLSVCSV YVVHDSLFGRPNCFQIVVQHFSEEHYIFYFAGETPEQAEDWMKGLQAFCN LRKSSPGTSNKRLRQVSSLVLHIEEAHKLPVKHFTNPYCNIYLNSVQVAK THAREGQNPVWSEEFVFDDLPPDINRFEITLSNKTKKSKDPDILFMRCQL SRLQKGHATDEWFLLSSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFK ELILQKELHVVYALSHVCGQDRTLLASILLRIFLHEKLESLLLCTLNDRE ISMEDEATTLFRATTLASTLMEQYMKATATQFVHHALKDSILKIMESKQS CELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMASEILPPTLRYIYGCL QKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPSPIAA RTLILVAKSVQNLANLVEFGAKEPYMEGVNPFIKSNKHRMIMFLDELGNV PELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLL AITELLQQKQNQYTKTNDVR
    • 分子量122 kDa including tags
    • 領域1 to 870

関連製品

特性

Our Abpromise guarantee covers the use of ab116964 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • CM AVM
    • CMAVM
    • DKFZp434N071
    • GAP
    • GTPase activating protein
    • GTPase-activating protein
    • OTTHUMP00000222390
    • OTTHUMP00000222391
    • OTTHUMP00000222392
    • OTTHUMP00000222393
    • p120GAP
    • p120RASGAP
    • PKWS
    • Ras GTPase-activating protein 1
    • Ras p21 protein activator
    • RAS p21 protein activator (GTPase activating protein) 1
    • RASA
    • RASA1
    • RASA1_HUMAN
    • RasGAP
    • Triphosphatase activating protein
    see all
  • 機能Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.
  • 組織特異性In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).
  • 関連疾患Note=Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas.
    Defects in RASA1 are the cause of capillary malformation-arteriovenous malformation (CMAVM) [MIM:608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome.
    Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.
  • 配列類似性Contains 1 C2 domain.
    Contains 1 PH domain.
    Contains 1 Ras-GAP domain.
    Contains 2 SH2 domains.
    Contains 1 SH3 domain.
  • 翻訳後修飾The N-terminus is blocked.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Recombinant Human RASA1 protein 画像

  • 12.5% SDS-PAGE showing ab116964 at approximately 121.77kDa stained with Coomassie Blue.

Recombinant Human RASA1 protein (ab116964) 使用論文

ab116964 has not yet been referenced specifically in any publications.

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