Recombinant Human Raptor protein (ab112419)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q8N122-2
    • 生物種Human
    • 配列MESEMLQSPLLGLGEEDEADLTDWNLPLAFMKKRHCEKIEGSKSLAQSWR MKDRMKTVSVALVLCLNVGVDPPDVVKTTPCARLECWIDPLSMGPQKALE TIGANLQKQYENWQPRARYKQSLDPTVDEVKKLCTSLRRNAKEERVLFHY NGHGVPRPTVNGEVWVFNKNYTQYIPLSIYDLQTWMGSPSIFVYDCSNAG LIVKSFKQFALQREQELEVAAINPNHPLAQMPLPPSMKNCIQLAACEATE LLPMIPDLPADLFTSCLTTPIKIALRWFCMQKCVSLVPGVTLDLIEKIPG RLNDRRTPLGELNWIFTAITDTIAWNVLPRDLFQKLFRQDLLVASLFRNF LLAERIMRSYNCTPVSSPRLPPTYMHAMW
    • 分子量68 kDa including tags
    • 領域1 to 379

特性

Our Abpromise guarantee covers the use of ab112419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態Liquid
  • 備考Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

関連情報

  • 別名
    • KIAA1303
    • KOG1
    • Mip1
    • P150 target of rapamycin (TOR) scaffold protein
    • p150 target of rapamycin (TOR) scaffold protein containing WD repeats
    • P150 target of rapamycin (TOR)-scaffold protein
    • Raptor
    • Regulatory associated protein of mTOR
    • Regulatory associated protein of MTOR complex 1
    • Regulatory-associated protein of mTOR
    • RPTOR
    • RPTOR_HUMAN
    see all
  • 機能Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.
  • 組織特異性Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta.
  • 配列類似性Belongs to the WD repeat RAPTOR family.
    Contains 7 WD repeats.
  • 細胞内局在Cytoplasm. Lysosome. Targeting to lysosomes depends on amino acid availability.
  • Information by UniProt

Recombinant Human Raptor protein 画像

  • ab112419 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Raptor protein (ab112419) 使用論文

ab112419 has not yet been referenced specifically in any publications.

Product Wall

The protein is tagged at the N terminus.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"