機能Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells.
組織特異性Expressed in red blood cells (at protein level).
配列類似性Belongs to the small GTPase superfamily. Ras family.
ドメインThe effector domain mediates the interaction with RUNDC3A.
翻訳後修飾Palmitoylated. Palmitoylation is required for association with recycling endosome membranes and activation of TNIK.
細胞内局在Recycling endosome membrane. Associated with red blood cells-released vesicles.