Recombinant Human Ran (mutated T24N) protein (ab90206)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE
製品の詳細
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製品名
Recombinant Human Ran (mutated T24N) protein
Ran タンパク質・ペプチド 製品一覧 -
精製度
> 95 % SDS-PAGE.
Protein preparation is 18% GDP-loaded, measured by HPLC. -
発現系
Escherichia coli -
タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
修飾
mutated T24N
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab90206 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
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製品の状態
Liquid -
備考
Ran T24N mutation results in no or little binding to GTP and is known to act as a negative inhibitor of nuclear import.
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.00
Constituents: 0.1001% DTE (1,4-Dithioerythritol), 1.125% Potassium chloride, 0.42% Potassium phosphate, 0.0475% Magnesium chloride, 10% Glycerol
関連情報
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別名
- Androgen receptor associated protein 24
- Androgen receptor-associated protein 24
- ARA 24
see all -
機能
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases. -
組織特異性
Expressed in a variety of tissues. -
配列類似性
Belongs to the small GTPase superfamily. Ran family. -
翻訳後修飾
The N-terminus is blocked. -
細胞内局在
Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab90206 は論文での使用が確認できていません。