Recombinant Human Ran (mutated Q69 L) protein (ab90208)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 修飾mutated Q69L

特性

Our Abpromise guarantee covers the use of ab90208 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Protein preparation is 34% GDP- and 17% GTP-loaded, measured by HPLC.
  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • 備考


    Ran Q69L is defective in GTP hydrolysis and is useful as a negative control for Ran binding and import studies.

    Protein preparation is 34% GDP- and 17% GTP-loaded, measured by HPLC.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50mM Potassium phosphate, 5mM Magnesium chloride, 5mM DTE (1, 4-Dithioerythritol), pH 7.5

関連情報

  • 別名
    • Androgen receptor associated protein 24
    • Androgen receptor-associated protein 24
    • ARA 24
    • ARA24
    • Gsp1
    • GTP binding nuclear protein RAN
    • GTP-binding nuclear protein Ran
    • GTPase Ran
    • Guanosine triphosphatase Ran
    • LPS
    • OK/SW-cl.81
    • ran
    • RAN member RAS oncogene family
    • RAN_HUMAN
    • RanGTPase
    • Ras like protein TC4
    • Ras related nuclear protein
    • Ras-like protein TC4
    • Ras-related nuclear protein
    • RASL2 8
    • TC 4
    • TC4
    see all
  • 機能GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules.
    Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
  • 組織特異性Expressed in a variety of tissues.
  • 配列類似性Belongs to the small GTPase superfamily. Ran family.
  • 翻訳後修飾The N-terminus is blocked.
  • 細胞内局在Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

Recombinant Human Ran (mutated Q69 L) protein (ab90208) 使用論文

ab90208 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"