Recombinant Human Rab11A protein (ab117177)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P62491
    • 生物種Human
    • 配列MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGTR DDEYDYLFKV VLIGDSGVGK SNLLSRFTRN EFNLESKSTI GVEFATRSIQ VDGKTIKAQI WDTAGQERYR AITSAYYRGA VGALLVYDIA KHLTYENVER WLKELRDHAD SNIVIMLVGN KSDLRHLRAV PTDEARAFAE KNGLSFIETS ALDSTNVEAA FQTILTEIYR IVSQKQMSDR RENDMSPSNN VVPIHVPPTT ENKPKVQCC
    • 分子量28 kDa including tags
    • 領域1 to 213
    • タグHis tag N-Terminus
    • 配列の追加情報RAB11A Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 249 amino acids (1-213a.a.) and having a molecular mass of 28.1 kDa.

特性

Our Abpromise guarantee covers the use of ab117177 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 90 % SDS-PAGE.
    ab117177 is purified by standard chromatography.
  • 製品の状態Liquid
  • 備考ab117177 although stable at 4°C for 1 week, should be stored desiccated below -18°C. Please prevent freeze thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 0.03% EDTA, 20% Glycerol

関連情報

  • 別名
    • MGC1490
    • Rab 11
    • Rab 11A
    • RAB 11A, member oncogene family
    • Rab-11
    • RAB11
    • RAB11 A
    • Rab11a
    • RAB11A member RAS oncogene family
    • Ras related protein Rab 11A
    • Ras related protein Rab11A
    • Ras-related protein Rab-11A
    • RB11A_HUMAN
    • YL 8
    • YL8
    see all
  • 機能Regulates endocytic recycling. May exert its functions by interacting with multiple effector proteins in different complexes. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes.
  • 配列類似性Belongs to the small GTPase superfamily. Rab family.
  • 細胞内局在Cell membrane. Recycling endosome membrane. Cleavage furrow. Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and luminogenesis.
  • Information by UniProt

Recombinant Human Rab11A protein (ab117177) 使用論文

ab117177 has not yet been referenced specifically in any publications.

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