Recombinant Human PXR protein (ab82082)

製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus
  • アミノ酸配列
    • 生物種
      Human

関連製品

特性

Our Abpromise guarantee covers the use of ab82082 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    1 unit equals 1 nanogram of purified protein. ab82082 binds to DNA as a heterodimer with RXR alpha; 1000U (1ug) required.
  • アプリケーション

    EMSA

  • 製品の状態
    Liquid
  • 備考
    1 unit equals 1 nanogram of purified protein. ab82082 binds to DNA as a heterodimer with RXR alpha; 1000U (1ug) required.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

関連情報

  • 別名
    • BXR
    • Nr1i2
    • NR1I2_HUMAN
    • Nuclear receptor subfamily 1 group I member 2
    • ONR 1
    • ONR1
    • Orphan nuclear receptor PAR 1
    • Orphan nuclear receptor PAR1
    • Orphan nuclear receptor PXR
    • OTTHUMP00000215173
    • OTTHUMP00000215174
    • OTTHUMP00000215175
    • PAR
    • PAR 1
    • PAR 2
    • PAR q
    • PAR1
    • PAR2
    • PARq
    • pregnane X nuclear receptor variant 2
    • Pregnane X receptor
    • PRR
    • PXR
    • SAR
    • Steroid and xenobiotic receptor
    • SXR
    see all
  • 機能
    Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
  • 組織特異性
    Expressed in liver, colon and small intestine.
  • 配列類似性
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

参考文献

ab82082 has not yet been referenced specifically in any publications.

レビューと Q&A

Abreviews
Application
Western blot
This product was used as a control protein for screening PXR antibodies and western blotting of cell lysates.
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Verified customer

投稿 Sep 03 2014

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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