製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q03393
    • 生物種Human
    • 配列MGSSHHHHHH SSGLVPRGSH MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE.
    • 分子量19 kDa including tags
    • 領域1 to 145
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab116410 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    ab116410 was purified by proprietary chromatographic techniques and filter sterilized.
  • 製品の状態Liquid
  • 備考Although stable at 4°C for 4 weeks, ab116410 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 20% Glycerol, 0.32% Tris HCl, 0.02% DTT

関連情報

  • 別名
    • 6 pyruvoyl tetrahydrobiopterin synthase
    • 6 pyruvoyl tetrahydropterin synthase
    • 6 pyruvoyltetrahydropterin synthase
    • 6-pyruvoyl tetrahydrobiopterin synthase
    • EC 4.2.3.12
    • FLJ97081
    • OTTHUMP00000235385
    • PTP synthase
    • PTPS
    • PTPS_HUMAN
    • PTS
    see all
  • 機能Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin.
  • パスウェイCofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from 7,8-dihydroneopterin triphosphate: step 1/3.
  • 関連疾患Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A) [MIM:261640]; also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.
  • 配列類似性Belongs to the PTPS family.
  • 翻訳後修飾Phosphorylation of Ser-19 is required for maximal enzyme activity.
  • Information by UniProt

Recombinant Human PTS protein (ab116410) 使用論文

ab116410 has not yet been referenced specifically in any publications.

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