Folate hydrolase prostate specific membrane antigen 1
Folylpoly gamma glutamate carboxypeptidase
Glutamate carboxylase II
Glutamate carboxypeptidase 2
Glutamate carboxypeptidase II
Membrane glutamate carboxypeptidase
N acetylated alpha linked acidic dipeptidase 1
N-acetylated-alpha-linked acidic dipeptidase I
Prostate specific membrane antigen
Prostate specific membrane antigen variant F
Prostate-specific membrane antigen
Pteroylpoly gamma glutamate carboxypeptidase
機能Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
組織特異性Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.
配列類似性Belongs to the peptidase M28 family. M28B subfamily.
ドメインThe NAALADase activity is found in the central region, the dipeptidyl peptidase IV type activity in the C-terminal.
翻訳後修飾The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. The N-terminus is blocked.