Recombinant Human PSIP1/LEDGF protein (ab82128)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE, GSA
製品の詳細
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製品名
Recombinant Human PSIP1/LEDGF protein
PSIP1/LEDGF タンパク質・ペプチド 製品一覧 -
精製度
> 95 % SDS-PAGE.
Purified by affinity chromatography in combination with FPLC chromatography. -
発現系
Escherichia coli -
タンパク質長
Full length protein -
Animal free
No -
由来
Recombinant -
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生物種
Human -
配列の追加情報
The amino acid sequence for ab82128 corresponds to isoform 1 of the protein, which is also known as p75 and PSIP1. Accession number NM_033222.
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関連製品
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Related Products
特性
Our Abpromise guarantee covers the use of ab82128 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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アプリケーション
SDS-PAGE
Gel Supershift Assays
EMSA
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製品の状態
Liquid -
備考
This product was previously labelled as PSIP1
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Concentration information loading...
前処理および保存
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保存方法および安定性
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.9
Constituents: 0.75% Potassium chloride, 0.0154% DTT, 0.316% Tris HCl, 0.00584% EDTA, 20% Glycerol (glycerin, glycerine)
関連情報
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別名
- CLL associated antigen KW 7
- CLL-associated antigen KW-7
- Dense fine speckles 70 kDa protein
see all -
機能
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. -
組織特異性
Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions. -
関連疾患
Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4. -
配列類似性
Belongs to the HDGF family.
Contains 1 PWWP domain. -
ドメイン
Residues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain). -
翻訳後修飾
Phosphorylated upon DNA damage, probably by ATM or ATR. -
細胞内局在
Nucleus. Remains chromatin-associated throughout the cell cycle. - Information by UniProt
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab82128 は論文での使用が確認できていません。