製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human

特性

Our Abpromise guarantee covers the use of ab82128 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    EMSA

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris Cl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

関連情報

  • 別名
    • CLL associated antigen KW 7
    • CLL-associated antigen KW-7
    • Dense fine speckles 70 kDa protein
    • DFS 70
    • DFS70
    • LEDGF
    • Lens epithelium derived growth factor
    • Lens epithelium-derived growth factor
    • MGC74712
    • p52
    • p75
    • PAIP
    • PC4 and SFRS1 interacting protein
    • PC4 and SFRS1 interacting protein 1
    • PC4 and SFRS1 interacting protein 2
    • PC4 and SFRS1-interacting protein
    • PSIP 1
    • PSIP 2
    • Psip1
    • PSIP1_HUMAN
    • PSIP2
    • Transcriptional coactivator p75/p52
    see all
  • 機能Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.
  • 組織特異性Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
  • 関連疾患Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
  • 配列類似性Belongs to the HDGF family.
    Contains 1 PWWP domain.
  • ドメインResidues 340-417 are necessary and sufficient for the interaction with HIV-1 IN (IBD domain).
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus. Remains chromatin-associated throughout the cell cycle.
  • Information by UniProt

Recombinant Human PSIP1 protein (ab82128) 使用論文

ab82128 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"