製品の概要

  • 製品名
    Recombinant Human PROX1 protein
  • タンパク質長
    Protein fragment

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYT RYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAIND GVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNA IIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
    • 分子量
      22 kDa
    • 領域
      547 to 737

特性

Our Abpromise guarantee covers the use of ab54337 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.
    >95% by SDS-PHAGE & silver stain.
  • 製品の状態
    Lyophilised
  • 備考

    This product can be used as a positive control e.g. in Western analysis.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Constituent: PBS

  • 再構成
    Reconstitute in water to a concentration not lower than 50 µg/ml.

関連情報

  • 別名
    • Homeobox prospero like protein
    • Homeobox prospero like protein PROX1
    • Homeobox prospero-like protein PROX1
    • Prospero homeobox 1
    • Prospero homeobox protein 1
    • Prospero related homeobox 1
    • prospero-related homeobox gene 1
    • PROX 1
    • PROX-1
    • PROX1
    • PROX1_HUMAN
    • zgc:111888
    see all
  • 機能
    Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
  • 組織特異性
    Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
  • 配列類似性
    Belongs to the Prospero homeobox family.
    Contains 1 Prospero-type homeobox DNA-binding domain.
  • ドメイン
    The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • 細胞内局在
    Nucleus. RORG promotes its nuclear localization.
  • Information by UniProt

Recombinant Human PROX1 protein 画像

  • SDS-PAGE analysis of recombinant human PROX1 protein fragment (ab54337). The sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with Coomassie blue.

Recombinant Human PROX1 protein (ab54337) 使用論文

ab54337 has not yet been referenced specifically in any publications.

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