The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. >95% by SDS-PHAGE & silver stain.
This product can be used as a positive control e.g. in Western analysis.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
再構成Reconstitute in water to a concentration not lower than 50 µg/ml.
Homeobox prospero like protein
Homeobox prospero like protein PROX1
Homeobox prospero-like protein PROX1
Prospero homeobox 1
Prospero homeobox protein 1
Prospero related homeobox 1
prospero-related homeobox gene 1
機能Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
組織特異性Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
配列類似性Belongs to the Prospero homeobox family. Contains 1 Prospero-type homeobox DNA-binding domain.
ドメインThe prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
細胞内局在Nucleus. RORG promotes its nuclear localization.