Recombinant Human Protein phosphatase 1 inhibitor 3C (ab117033)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      DLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQM APQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR
    • 分子量
      36 kDa including tags
    • 領域
      221 to 317

特性

Our Abpromise guarantee covers the use of ab117033 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • OTTHUMP00000020089
    • Phosphatase 1, regulatory inhibitor subunit 5
    • PP1 subunit R5
    • ppp1r3c
    • PPP1R5
    • PPR3C_HUMAN
    • Protein phosphatase 1 regulatory subunit 3C
    • Protein phosphatase 1 regulatory subunit 5
    • protein phosphatase 1, regulatory (inhibitor) subunit 3C
    • Protein targeting to glycogen
    • PTG
    • R5
    see all
  • 機能
    Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
  • 配列類似性
    Contains 1 CBM21 (carbohydrate binding type-21) domain.
  • ドメイン
    The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.
  • 翻訳後修飾
    Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.
  • Information by UniProt

画像

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab117033 at approximately 36.30 kDa.

参考文献

ab117033 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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