Recombinant Human Protein Phosphatase 1 beta (ab126018)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P62140
    • 生物種Human
    • 領域30 to 319

特性

Our Abpromise guarantee covers the use of ab126018 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成Reconstitute with water to desired concentration.

関連情報

  • 別名
    • MGC3672
    • PP 1B
    • PP-1B
    • PP1B
    • PP1B_HUMAN
    • PP1beta
    • PPP1CB
    • PPP1CD
    • Protein phosphatase 1 beta
    • Protein phosphatase 1 catalytic subunit beta isoform
    • Protein phosphatase 1 delta
    • Protein phosphatase 1, catalytic subunit, beta isozyme
    • Protein phosphatase 1, catalytic subunit, delta isoform
    • Serine threonine protein phosphatase PP1 beta catalytic subunit
    • Serine/threonine-protein phosphatase PP1-beta catalytic subunit
    see all
  • 機能Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
  • 配列類似性Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 細胞内局在Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
  • Information by UniProt

Recombinant Human Protein Phosphatase 1 beta (ab126018) 使用論文

ab126018 has not yet been referenced specifically in any publications.

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