Recombinant Human Protein Kinase A regulatory subunit I alpha (ab125532)

法規制情報

関連情報

• 別名
  • ACRDYS1
  • ADOHR
  • cAMP dependent protein kinase regulatory subunit alpha 1

  • cAMP dependent protein kinase regulatory subunit RIalpha
  • cAMP dependent protein kinase type I alpha regulatory chain
  • cAMP dependent protein kinase type I alpha regulatory subunit
  • cAMP-dependent protein kinase type I-alpha regulatory subunit
  • CAR
  • Carney complex type 1
  • CNC
  • CNC 1
  • CNC1
  • DKFZp779L0468
  • KAP0_HUMAN
  • MGC17251
  • PKA RIA
  • PKR 1
  • PKR1
  • PPNAD 1
  • PPNAD1
  • PRKAR 1
  • PRKAR1
  • PRKAR1A
  • PRKAR1A/RARA FUSION GENE
  • Protein kinase A type 1a regulatory subunit
  • Protein kinase cAMP dependent regulatory type I alpha
  • PTC2 CHIMERIC ONCOGENE, INCLUDED
  • Tissue specific extinguisher 1
  • Tissue-specific extinguisher 1
  • TSE 1
  • TSE1

  see all
• 組織特異性
  Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
• 関連疾患
  Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1) [MIM:160980]. CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
  Defects in PRKAR1A are the cause of intracardiac myxoma (INTMYX) [MIM:255960]. Inheritance is autosomal recessive.
  Defects in PRKAR1A are the cause of primary pigmented nodular adrenocortical disease type 1 (PPNAD1) [MIM:610489]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. PPNAD1 is most often diagnosed in patients with Carney complex, but it can also be observed in patients without other manifestations or familial history.
• 配列類似性
  Belongs to the cAMP-dependent kinase regulatory chain family.
  Contains 2 cyclic nucleotide-binding domains.
• 翻訳後修飾
  The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.

• Target information above from: UniProt accession P10644 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt