Recombinant Human Protein Kinase A regulatory subunit I alpha (ab125532)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号P10644
    • 生物種Human
    • 分子量51 kDa including tags
    • 領域1 to 381

特性

Our Abpromise guarantee covers the use of ab125532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度> 85 % Densitometry.
    Purity determined to be >85% by densitometry.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 0.002% PMSF, 0.82% Sodium phosphate, 0.0038% DTT, 25% Glycerol, 1.75% Sodium chloride

関連情報

  • 別名
    • ACRDYS1
    • ADOHR
    • cAMP dependent protein kinase regulatory subunit alpha 1
    • cAMP dependent protein kinase regulatory subunit RIalpha
    • cAMP dependent protein kinase type I alpha regulatory chain
    • cAMP dependent protein kinase type I alpha regulatory subunit
    • cAMP-dependent protein kinase type I-alpha regulatory subunit
    • CAR
    • Carney complex type 1
    • CNC
    • CNC 1
    • CNC1
    • DKFZp779L0468
    • KAP0_HUMAN
    • MGC17251
    • PKA RIA
    • PKR 1
    • PKR1
    • PPNAD 1
    • PPNAD1
    • PRKAR 1
    • PRKAR1
    • PRKAR1A
    • PRKAR1A/RARA FUSION GENE
    • Protein kinase A type 1a regulatory subunit
    • Protein kinase cAMP dependent regulatory type I alpha
    • PTC2 CHIMERIC ONCOGENE, INCLUDED
    • Tissue specific extinguisher 1
    • Tissue-specific extinguisher 1
    • TSE 1
    • TSE1
    see all
  • 組織特異性Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 関連疾患Defects in PRKAR1A are the cause of Carney complex type 1 (CNC1) [MIM:160980]. CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
    Defects in PRKAR1A are the cause of intracardiac myxoma (INTMYX) [MIM:255960]. Inheritance is autosomal recessive.
    Defects in PRKAR1A are the cause of primary pigmented nodular adrenocortical disease type 1 (PPNAD1) [MIM:610489]. Primary pigmented nodular adrenocortical disease is a rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. PPNAD1 is most often diagnosed in patients with Carney complex, but it can also be observed in patients without other manifestations or familial history.
  • 配列類似性Belongs to the cAMP-dependent kinase regulatory chain family.
    Contains 2 cyclic nucleotide-binding domains.
  • 翻訳後修飾The pseudophosphorylation site binds to the substrate-binding region of the catalytic chain, resulting in the inhibition of its activity.
  • Information by UniProt

Recombinant Human Protein Kinase A regulatory subunit I alpha 画像

  • SDS-PAGE analysis of ab125532.

Recombinant Human Protein Kinase A regulatory subunit I alpha (ab125532) 使用論文

ab125532 has not yet been referenced specifically in any publications.

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