Recombinant Human Prostaglandin dehydrogenase 1 protein (ab99298)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号P15428
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSHMHVNGKVALVTGAAQGIGRAFAEALLLKGA KVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDVADQQQLRDTFRKVVD HFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEG GIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLI TLIEDDALNGAIMKITTSKGIHFQDYDTTPFQAKTQ
    • 分子量31 kDa including tags
    • 領域1 to 266
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab99298 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    Mass Spectrometry

  • 質量分析
    MALDI-TOF
  • 精製度> 95 % SDS-PAGE.
    ab99298 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0

関連情報

  • 別名
    • 15 hydroxyprostaglandin dehydrogenase [NAD+]
    • 15 PGDH
    • 15-hydroxyprostaglandin dehydrogenase [NAD+]
    • 15-PGDH
    • 15PGDH
    • Hpgd
    • Hydroxyprostaglandin dehydrogenase 15 (NAD)
    • NAD+ dependent 15 hydroxyprostaglandin dehydrogenase
    • OTTHUMP00000218960
    • OTTHUMP00000219016
    • OTTHUMP00000219018
    • PGDH
    • PGDH_HUMAN
    • PGDH1
    • PHOAR1
    • Prostaglandin dehydrogenase 1
    • SDR36C1
    • Short chain dehydrogenase/reductase family 36C member 1
    see all
  • 機能Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
  • 組織特異性Detected in colon epithelium (at protein level).
  • 関連疾患Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR) [MIM:259100]; also known as pachydermoperiostosis autosomal recessive. Primary hypertrophic osteoarthropathy is characterized by digital clubbing, osterarthropathy, variable features of pachydermia, delayed closure of the fontanels, and congenital heart disease.
    Defects in HPGD are the cause of cranioosteoarthropathy (COA) [MIM:259100]. Clinical features include infantile onset of swelling of the joints, digital clubbing, hyperhidrosis, delayed closure of the fontanels, periostosis, and variable patent ductus arteriosus. Pachydermia is not a prominent feature.
    Defects in HPGD are a cause of isolated congenital nail clubbing (ICNC) [MIM:119900]; also called clubbing of digits or hereditary acropachy. ICNC is a rare genodermatosis characterized by enlargement of the nail plate and terminal segments of the fingers and toes, resulting from proliferation of the connective tissues between the nail matrix and the distal phalanx. It is usually symmetrical and bilateral (in some cases unilateral). In nail clubbing usually the distal end of the nail matrix is relatively high compared to the proximal end, while the nail plate is complete but its dimensions and diameter more or less vary in comparison to normal. There may be different fingers and toes involved to varying degrees. Some fingers or toes are spared, but the thumbs are almost always involved.
  • 配列類似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 細胞内局在Cytoplasm.
  • Information by UniProt

Recombinant Human Prostaglandin dehydrogenase 1 protein 画像

  • 15% SDS-PAGE showing ab99298 (3µg).

Recombinant Human Prostaglandin dehydrogenase 1 protein (ab99298) 使用論文

ab99298 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab99298.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"