製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MHHHHHHMKI EEGKLVIWIN GDKGYNGLAE VGKKFEKDTG IKVTVEHPDK LEEKFPQVAA TGDGPDIIFW AHDRFGGYAQ SGLLAEITPD KAFQDKLYPF TWDAVRYNGK LIAYPIAVEA LSLIYNKDLL PNPPKTWEEI PALDKELKAK GKSALMFNLQ EPYFTWPLIA ADGGYAFKYE NGKYDIKDVG VDNAGAKAGL TFLVDLIKNK HMNADTDYSI AEAAFNKGET AMTINGPWAW SNIDTSKVNY GVTVLPTFKG QPSKPFVGVL SAGINAASPN KELAKEFLEN YLLTDEGLEA VNKDKPLGAV ALKSYEEELA KDPRIAATME NAQKGEIMPN IPQMSAFWYA VRTAVINAAS GRQTVDEALK DAQTNSSSNN NNNNNNNNLG IEGRGSHMAA AEAANCIMEV SCGQAESSEK PNAEDMTSKD YYFDSYAHFG IHEEMLKDEV RTLTYRNSMF HNRHLFKDKV VLDVGSGTGI LCMFAAKAGA RKVIGIECSS ISDYAVKIVK ANKLDHVVTI IKGKVEEVEL PVEKVDIIIS EWMGYCLFYE SMLNTVLYAR DKWLAPDGLI FPDRATLYVT AIEDRQYKDY KIHWWENVYG FDMSCIKDVA IKEPLVDVVD PKQLVTNACL IKEVDIYTVK VEDLTFTSPF CLQVKRNDYV HALVAYFNIE FTRCHKRTGF STSPESPYTH WKQTVFYMED YLTVKTGEEI FGTIGMRPNA KNNRDLDFTI DLDFKGQLCE LSCSTDYRMR

特性

Our Abpromise guarantee covers the use of ab89007 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Specific Activity: 10,000unit/ml. Unit Definition : One unit will transfer 1pmol of methyl group to synthetic peptide of histone H4 for 10 minutes at 37C.
  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 精製度> 90 % SDS-PAGE.
    ab89007 is purified using conventional chromatography techniques.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 40% Glycerol, 40mM Tris, 4mM Magnesium chloride, 2mM DTT, 100mM Sodium chloride, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • ANM 1
    • ANM1
    • ANM1_HUMAN
    • HCP 1
    • HCP1
    • Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2
    • Heterogeneous nuclear ribonucleoproteins methyltransferase like 2
    • Heterogeneous nuclear ribonucleoproteins methyltransferase like2
    • Histone-arginine N-methyltransferase PRMT1
    • HMT 2
    • HMT1 (hnRNP methyltransferase S. cerevisiae) like 2
    • HMT1 hnRNP methyltransferase
    • HMT1 hnRNP methyltransferase like 2
    • HMT1 hnRNP methyltransferase like 2 (S. cerevisiae)
    • HMT2
    • HRMT1 L2
    • HRMT1L 2
    • HRMT1L2
    • Human mRNA for suppressor for yeast mutant
    • Human mRNA for suppressor for yeast mutant complete cds
    • Interferon receptor 1 bound protein 4
    • Interferon receptor 1 bound protein4
    • Interferon receptor 1-bound protein 4
    • Interferon receptor 1bound protein 4
    • IR1 B4
    • IR1B 4
    • IR1B4
    • Mrmt 1
    • Mrmt1
    • PRMT 1
    • PRMT1
    • Protein arginine methyltransferase 1
    • Protein arginine N methyltransferase 1
    • Protein arginine N methyltransferase1
    • Protein arginine N-methyltransferase 1
    • R1B4
    • S. cerevisiae like 2
    see all
  • 機能Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway.
  • 組織特異性Widely expressed.
  • 配列類似性Belongs to the protein arginine N-methyltransferase family.
  • 細胞内局在Nucleus. Cytoplasm > cytosol.
  • Information by UniProt

Recombinant human PRMT1 protein 画像

  • 15% SDS-PAGE analysis of 3µg ab89007

Recombinant human PRMT1 protein (ab89007) 使用論文

ab89007 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"