Recombinant Human Presenilin 2 protein (ab114427)

製品の概要

  • 製品名Recombinant Human Presenilin 2 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P49810
    • 生物種Human
    • 配列MLTFMASDSEEEVCDERTSLMSAESPTPRSCQEGRQGPEDGENTAQWRSQ ENEEDGEEDPDRYVCSGVPGRPPGLEEELTLKYGAK
    • 分子量35 kDa including tags
    • 領域1 to 86

関連製品

特性

Our Abpromise guarantee covers the use of ab114427 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • AD3L
    • AD3LP
    • AD4
    • AD5
    • Alzheimer disease 4
    • CMD1V
    • E5-1
    • OTTHUMP00000035671
    • OTTHUMP00000035672
    • OTTHUMP00000228286
    • OTTHUMP00000228288
    • Presenilin 2
    • Presenilin 2 (Alzheimer disease 4)
    • Presenilin-2 CTF subunit
    • PS-2
    • PS2
    • Psen2
    • PSN2_HUMAN
    • PSNL2
    • STM-2
    • STM2
    see all
  • 機能Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
  • 組織特異性Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
  • 関連疾患Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889]. AD is an autosomal dominant Alzheimer disease. Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death.
    Defects in PSEN2 are the cause of cardiomyopathy dilated type 1V (CMD1V) [MIM:613697]. It is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 配列類似性Belongs to the peptidase A22A family.
  • ドメインThe PAL motif is required for normal active site conformation.
  • 翻訳後修飾Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments.
    Phosphorylated on serine residues.
  • 細胞内局在Endoplasmic reticulum membrane. Golgi apparatus membrane.
  • Information by UniProt

Recombinant Human Presenilin 2 protein 画像

  • ab114427 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Presenilin 2 protein (ab114427) 使用論文

ab114427 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"