製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P50897
    • 生物種Human
    • 配列MASPGCLWLLAVALLPWTCASRALQHLDPPAPLPLVIWHGMGDSCCNPLS MGAIKKMVEKKIPGIYVLSLEIGKTLMEDVENSFFLNVNSQVTTVCQALA KDPKLQQGYNAMGFSQGGQFLRAVAQRCPSPPMINLISVGGQHQGVFGLP RCPGESSHICDFIRKTLNAGAYSKVVQERLVQAEYWHDPIKEDVYRNHSI FLADINQERGINESYKKNLMALKKFVMVKFLNDSIVDPVDSEWFGFYRSG QAKETIPLQETSLYTQDRLGLKEMDNAGQLVFLATEGDHLQLSEEWFYAH IIPFLG
    • 分子量60 kDa including tags
    • 領域1 to 306

特性

Our Abpromise guarantee covers the use of ab116764 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • Ceroid palmitoyl palmitoyl protein thioesterase 1
    • CLN1
    • EC 3.1.2.22
    • INCL
    • Palmitoyl protein hydrolase 1
    • Palmitoyl protein thioesterase 1
    • Palmitoyl-protein hydrolase 1
    • Palmitoyl-protein thioesterase 1
    • PPT
    • PPT-1
    • PPT1
    • PPT1_HUMAN
    see all
  • 機能Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
  • 関連疾患Defects in PPT1 are the cause of neuronal ceroid lipofuscinosis type 1 (CLN1) [MIM:256730]. A form of neuronal ceroid lipofuscinosis with variable age at onset. Infantile, late-infantile, juvenile, and adult onset have been reported. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN1 is referred to as granular osmiophilic deposits (GROD).
  • 配列類似性Belongs to the palmitoyl-protein thioesterase family.
  • 細胞内局在Lysosome.
  • Information by UniProt

Recombinant Human PPT1 protein 画像

  • 12.5% SDS-PAGE analysis of ab116764 at approximately 59.73kDa, stained with Coomassie Blue.

Recombinant Human PPT1 protein (ab116764) 使用論文

ab116764 has not yet been referenced specifically in any publications.

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