製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P60510
    • 生物種Human
    • 配列GSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCG NVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL
    • 分子量36 kDa including tags
    • 領域218 to 307

特性

Our Abpromise guarantee covers the use of ab114693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • PP X
    • PP-X
    • Pp4
    • PP4C
    • PP4C_HUMAN
    • PPH3
    • PPP4
    • ppp4c
    • PPX
    • protein phosphatase 4 (formerly X), catalytic subunit
    • Protein phosphatase 4 catalytic subunit
    • Protein phosphatase X
    • protein phosphatase X, catalytic subunit
    • Serine/threonine protein phosphatase 4 catalytic subunit
    • Serine/threonine-protein phosphatase 4 catalytic subunit
    see all
  • 機能Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
  • 配列類似性Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
  • 細胞内局在Cytoplasm. Nucleus. Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt

Recombinant Human PPP4C protein 画像

  • 12.5% SDS-PAGE showing ab114693 at approximately 35.53 kDa stained with Coomassie Blue.

Recombinant Human PPP4C protein (ab114693) 使用論文

ab114693 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114693.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"