製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human
    • 配列MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWILMGAF LDKPKMEKHN AQGQGNGLRY GLSSMQGWRV EMEDAHTAVI GLPSGLESWS FFAVYDGHAG SQVAKYCCEH LLDHITNNQD FKGSAGAPSV ENVKNGIRTG FLEIDEHMRV MSEKKHGADR SGSTAVGVLI SPQHTYFINC GDSRGLLCRN RKVHFFTQDH KPSNPLEKER IQNAGGSVMI QRVNGSLAVS RALGDFDYKC VHGKGPTEQL VSPEPEVHDI ERSEEDDQFI ILACDGIWDV MGNEELCDFV RSRLEVTDDL EKVCNEVVDT CLYKGSRDNM SVILICFPNA PKVSPEAVKK EAELDKYLEC RVEEIIKKQG EGVPDLVHVM RTLASENIPS LPPGGELASK RNVIEAVYNR LNPYKNDDTD STSTDDMW
    • 領域1 to 382

特性

Our Abpromise guarantee covers the use of ab51205 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Specific activity: > 8,000units/mg of PPM1A. Unit Definition - one unit will hydrolyze 1 nanomole of p-nitrophenylphosphatate per minute at pH 7.4 at 37°C using 10mM of substrate.
  • アプリケーション

    SDS-PAGE

    Functional Studies

  • エンドトキシン・レベル< 1.000 Eu/µg
  • 質量分析
    MALDI-TOF
  • 精製度> 95 % SDS-PAGE.
    ab51205 was purified by conventional column chromatography.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 50mM Sodium chloride, 2mM DTT, 10mM Tris HCl, 1mM Manganese chloride, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Protein phosphatase 2C isoform alpha
    • EC 3.1.3.16
    • FLJ42306
    • IA
    • MGC9201
    • Mpp alpha
    • PP2C alpha
    • PP2C-alpha
    • PP2CA
    • PP2Calpha
    • PPM 1A
    • PPM1A
    • PPM1A_HUMAN
    • PPPM1A
    • Protein phosphatase 1A
    • Protein phosphatase 1A (formerly 2C) magnesium dependent alpha isoform
    • Protein phosphatase 1A magnesium dependent alpha
    • Protein phosphatase 2C alpha
    • Protein phosphatase 2C alpha isoform
    • Protein phosphatase 2C isoform alpha
    • Protein phosphatase IA
    • Protein phosphatase, Mg2+/Mn2+ dependent, 1A
    see all
  • 機能Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling.
  • 配列類似性Belongs to the PP2C family.
  • 細胞内局在Nucleus.
  • Information by UniProt

Recombinant human PPM1A protein 画像

  • 10% SDS-PAGE gel loaded with ab51205, PP2C alpha protein (His tag).
    Predicted molecular weight 46.6 kDa.

Recombinant human PPM1A protein (ab51205) 使用論文

ab51205 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"