製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHHSSGLVPRGSHMGIKVQRPRCFFDIAINNQPAGRVVFELFS DVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFS EGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKP TPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCG
    • 分子量
      22 kDa including tags
    • 領域
      1 to 175
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab117666 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Specific activity is > 75 nmoles/min/ug, and is defined as the amount of enzyme that will cleave 1umole of suc-AAFP-pNA per minute at 1C in Tris-Hcl pH8.0 using chymotrypsin.
  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 精製度
    > 95 % SDS-PAGE.
    ab117666 is purified by proprietary chromatographic techniques.
  • 製品の状態
    Liquid
  • 備考
    Although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Please see notes section.

    pH: 8.00
    Constituents: 0.24% Tris, 0.02% DTT, 10% Glycerol

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • CARS cyclophilin
    • CARS Cyp
    • CARS-cyclophilin
    • CARS-Cyp
    • CASP 10
    • CASP10
    • Clk associating RS cyclophilin
    • Clk-associating RS-cyclophilin
    • Cyclophilin G
    • CyclophilinG
    • CYP
    • MGC133241
    • Peptidyl prolyl cis trans isomerase G
    • Peptidyl prolyl isomerase G
    • Peptidyl prolyl isomerase G (cyclophilin G)
    • Peptidyl-prolyl cis-trans isomerase G
    • Peptidyl-prolyl isomerase G
    • Peptidylprolyl isomerase G
    • Peptidylprolyl isomerase G (cyclophilin G)
    • PPIase G
    • Ppig
    • PPIG_HUMAN
    • Rotamase G
    • RotamaseG
    • SCAF10
    • SR cyclophilin
    • SR cyp
    • SR related CTD associated factor 10
    • SR-cyclophilin
    • SR-cyp
    • SRcyp
    see all
  • 機能
    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
  • 組織特異性
    Ubiquitous.
  • 配列類似性
    Contains 1 PPIase cyclophilin-type domain.
  • ドメイン
    The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II.
  • 翻訳後修飾
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在
    Nucleus matrix. Nucleus speckle. Colocalizes with RNA splicing factors at nuclear speckles.
  • Information by UniProt

参考文献

ab117666 has not yet been referenced specifically in any publications.

レビューと Q&A

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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