Recombinant Human POT1 protein (ab112404)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q9NUX5
    • 生物種Human
    • 配列MSLVPATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIV DQTNVKLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQG
    • 分子量36 kDa including tags
    • 領域1 to 95

特性

Our Abpromise guarantee covers the use of ab112404 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態Liquid
  • 備考Best to use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

関連情報

  • 別名
    • DKFZP586D211
    • hPot 1
    • hPot1
    • POT 1
    • POT1
    • POT1 like telomere end-binding protein
    • POT1 protection of telomeres 1 homolog
    • POT1-like telomere end-binding protein
    • POTE1_HUMAN
    • Protection of telomeres 1
    • Protection of telomeres 1 homolog (S. pombe)
    • Protection of telomeres protein 1
    see all
  • 機能Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity by itself. In contrast, the ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.
  • 組織特異性Ubiquitous.
  • 配列類似性Belongs to the telombin family.
  • 細胞内局在Nucleus. Chromosome > telomere. Colocalizes with telomeric DNA.
  • Information by UniProt

Recombinant Human POT1 protein 画像

  • 12.5% SDS-PAGE analysis of ab112404. Stained with Coomassie Blue

Recombinant Human POT1 protein (ab112404) 使用論文

ab112404 has not yet been referenced specifically in any publications.

Product Wall

Thanks for your inquiry. ab112404 binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats(G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. It binds telomeric single-stranded sequenc...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"