製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • 生物種Human

関連製品

特性

Our Abpromise guarantee covers the use of ab53376 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 20mM Tris, pH 8

関連情報

  • 別名
    • A esterase 1
    • A-esterase 1
    • Aromatic esterase 1
    • Arylesterase 1
    • Arylesterase B type
    • ESA
    • Esterase A
    • K 45
    • K-45
    • MVCD5
    • Paraoxonase
    • Paraoxonase 1
    • Paraoxonase B type
    • Paraoxonase, plasma
    • Paraoxonase1
    • PON
    • PON 1
    • PON1
    • PON1_HUMAN
    • Serum aryldiakylphosphatase
    • Serum aryldialkylphosphatase 1
    • Serum paraoxonase/arylesterase 1
    see all
  • 機能Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
  • 組織特異性Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
  • 関連疾患Genetic variation in PON1 is associated with susceptibility to microvascular complications of diabetes type 5 (MVCD5) [MIM:612633]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Homozygosity for the Leu-54 allele is strongly associated with the development of retinal disease in diabetic patients.
  • 配列類似性Belongs to the paraoxonase family.
  • 翻訳後修飾Glycosylated.
    The signal sequence is not cleaved.
    Present in two forms, form B contains a disulfide bond, form A does not.
  • 細胞内局在Secreted > extracellular space.
  • Information by UniProt

Recombinant Human PON1 protein 画像

  • SDS Page analysis of ab53376.
  • Anti-PON1 antibody [17A12] (ab24261) at 1/500 dilution + Recombinant Human PON1 protein (ab53376) at 0.01 µg

    Secondary
    Goat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/500 dilution
    Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 1 minute

Recombinant Human PON1 protein (ab53376) 使用論文

ab53376 has not yet been referenced specifically in any publications.

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