Recombinant Human Polycystin 2 protein (ab114461)

製品の概要

  • 製品名Recombinant Human Polycystin 2 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号Q13563
    • 生物種Human
    • 配列PVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKMQPSNQTEADNRSFIF YENLLLGVPRIRQLRVRNGSCSIPQDLRDEIKECYDVYSVSSEDRAPFGP
    • 分子量37 kDa including tags
    • 領域261 to 360

関連製品

特性

Our Abpromise guarantee covers the use of ab114461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

    ELISA

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    ab114461 is best used within three months from the date of receipt.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

関連情報

  • 別名
    • APKD2
    • Autosomal dominant polycystic kidney disease type II
    • Autosomal dominant polycystic kidney disease type II protein
    • MGC138466
    • MGC138468
    • PC 2
    • PC2
    • PKD 2
    • PKD2
    • PKD2_HUMAN
    • PKD4
    • Polycystic kidney disease 2
    • Polycystic kidney disease 2 (autosomal dominant)
    • Polycystic kidney disease 2 protein
    • Polycystin 2
    • Polycystin 2 transient receptor potential cation channel
    • Polycystin-2
    • Polycystin2
    • Polycystwin
    • R48321
    • Transient receptor potential cation channel subfamily P member 2
    • TRPP2
    see all
  • 機能Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
  • 組織特異性Strongly expressed in ovary, fetal and adult kidney, testis, and small intestine. Not detected in peripheral leukocytes.
  • 関連疾患Defects in PKD2 are the cause of polycystic kidney disease autosomal dominant type 2 (ADPKD2) [MIM:613095]. ADPKD2 is a disorder characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. It represents approximately 15% of the cases of autosomal dominant polycystic kidney disease. ADPKD2 is clinically milder than ADPKD1 but it has a deleterious impact on overall life expectancy.
  • 配列類似性Belongs to the polycystin family.
    Contains 1 EF-hand domain.
  • ドメインThe C-terminal coiled-coil domain binds calcium and undergoes a calcium-induced conformation change. It is implicated in oligomerization and the interaction with PKD1.
  • 細胞内局在Membrane. Endoplasmic reticulum.
  • Information by UniProt

Recombinant Human Polycystin 2 protein 画像

  • ab114461 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human Polycystin 2 protein (ab114461) 使用論文

ab114461 has not yet been referenced specifically in any publications.

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