Recombinant Human Podoplanin / gp36 protein (ab117687)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MGSSHHHHHH SSGLVPRGSH MASTGQPEDD TETTGLEGGV AMPGAEDDVV TPGTSEDRYK SGLTTLVATS VNSVTGIRIE DLPTSESTVH AQEQSPSATA SNVATSHSTE KVDGDTQTTV EKDGLSTVTL
    • 分子量
      13 kDa including tags
    • 領域
      23 to 131
    • タグ
      His tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab117687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    HPLC

    SDS-PAGE

  • 精製度
    > 95 % SDS-PAGE.
    Purity was determined to be greater than 95% as determined by RP-HPLC and SDS-PAGE.
  • 製品の状態
    Liquid
  • 備考
    Although stable 4°C for 4 weeks, ab117687 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Please see notes section.

    pH: 7.50
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

関連情報

  • 別名
    • Aggrus
    • Glycoprotein 36 KD
    • Glycoprotein 36
    • gp 36
    • GP 38
    • GP 40
    • gp36
    • GP38
    • GP40
    • HT1A 1
    • HT1A1
    • hT1alpha 1
    • hT1alpha 2
    • hT1alpha1
    • hT1alpha2
    • Lung type I cell membrane associated glycoprotein
    • Lung type I cell membrane associated glycoprotein isoform a
    • Lung type I cell membrane associated glycoprotein T1A 2
    • OTS 8
    • OTS8
    • OTTHUMP00000009640
    • OTTHUMP00000044504
    • PA2.26
    • PA2.26 antigen
    • Pdpn
    • PDPN_HUMAN
    • Podoplanin
    • PSEC0003
    • PSEC0025
    • T1 alpha
    • T1 ALPHA GENE
    • T1-alpha
    • T1A
    • T1A 2
    • TI1A
    • TIA 2
    • TIA2
    see all
  • 機能
    May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
  • 組織特異性
    Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors and expressed in 25% of early oral squamous cell carcinomas.
  • 配列類似性
    Belongs to the podoplanin family.
  • 翻訳後修飾
    Extensively O-glycosylated. Contains sialic acid residues. O-glycosylation is necessary for platelet aggregation activity.
    The N-terminus is blocked.
  • 細胞内局在
    Membrane. Cell projection > filopodium membrane. Cell projection > lamellipodium membrane. Cell projection > microvillus membrane. Cell projection > ruffle membrane. Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles.
  • Information by UniProt

Recombinant Human Podoplanin / gp36 protein (ab117687) 使用論文

ab117687 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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