製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号O00469
    • 生物種Human
    • 配列DSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWR GGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVL KKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYV NRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAV DEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQD NGCTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLTLDYPKE ALKLFIHNKEVYHEKDIKVFFDKAKHEIKTIKIVGPEENLSQAEARNMGM DFCRQDEKCDYYFSVDADVVLTNPRTLKILIEQNRKIIAPLVTRHGKLWS NFWGALSPDGYYARSEDYVDIVQGNRVGVWNVPYMANVYLIKGKTLRSEM NERNYFVRDKLDPDMALCRNAREMTLQREKDSPTPETFQMLSPPKGVFMY ISNRHEFGRLLSTANYNTSHYNNDLWQIFENPVDWKEKYINRDYSKIFTE NIVEQPCPDVFWFPIFSEKACDELVEEMEHYGKWSGGKHHDSRISGGYEN VPTDDIHMKQVDLENVWLHFIREFIAPVTLKVFAGYYTKGFALLNFVVKY SPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIESPRKG WSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP
    • 分子量107 kDa including tags
    • 領域27 to 758

特性

Our Abpromise guarantee covers the use of ab116924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • 2-oxoglutarate 5-dioxygenase 2
    • LH2
    • Lysine hydroxylase 2
    • Lysyl hydroxylase 2
    • OTTHUMP00000215204
    • OTTHUMP00000215205
    • OTTHUMP00000215206
    • PLOD 2
    • Plod2
    • PLOD2_HUMAN
    • Procollagen lysine 2 oxoglutarate 5 dioxygenase 2
    • Procollagen lysine, 2 oxoglutarate 5 dioxygenase (lysine hydroxylase) 2
    • Procollagen-lysine
    • Telopeptide lysyl hydroxylase
    • TLH
    see all
  • 機能Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
  • 組織特異性Highly expressed in pancreas and muscle. Isoform 1 and isoform 2 are expressed in the majority of the examined cell types. Isoform 2 is specifically expressed in skin, lung, dura and aorta.
  • 関連疾患Defects in PLOD2 are the cause of Bruck syndrome type 2 (BRKS2) [MIM:609220]. Bruck syndrome, also known as osteogenesis imperfecta with congenital joint contractures, is an autosomal recessive disease characterized by generalized osteopenia, joint contractures at birth, fragile bones and short stature. It can be distinguished from osteogenesis imperfecta by the absence of hearing loss and dentinogenesis imperfecta, and by the presence of clubfoot and congenital joint limitations. The molecular defect is an aberrant cross-linking of bone collagen, due to underhydroxylation of lysine residues within the telopeptides of type I collagen, whereas the lysine residues in the triple helix are normal.
  • 配列類似性Contains 1 Fe2OG dioxygenase domain.
  • 細胞内局在Rough endoplasmic reticulum membrane.
  • Information by UniProt

Recombinant Human PLOD2 protein 画像

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab116924 at approximately 106.63 kDa.

Recombinant Human PLOD2 protein (ab116924) 使用論文

ab116924 has not yet been referenced specifically in any publications.

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