Recombinant human PIK3CG + PIK3R5 protein (ab68181)

製品の概要

  • 製品名Recombinant human PIK3CG + PIK3R5 protein
  • タンパク質長Full length protein

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus infected Sf9 cells
  • アミノ酸配列
    • 生物種Human
    • 分子量30 kDa
    • 領域1 to 261
    • タグHis tag C-Terminus

特性

Our Abpromise guarantee covers the use of ab68181 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Activity: ~ 3 nmol/mg/min using phosphatidylinositol as the substrate.
  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.

  • 製品の状態Liquid
  • 備考For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50% Glycerol, 25mM Sodium chloride, 25mM HEPES, 2.5mM Magnesium chloride, pH 8.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • FOAP2
    • P101 PI3K
    • p120 PI3K
    • PI3 kinase catalitic gamma polypetide
    • PI3 kinase regulatory subunit 5
    • PI3K
    • PI3Kgamma
    • PIK3R5
    • Protein FOAP 2
    see all
  • 関連性PI3 Kinase catalytic subunit gamma belongs to a family of lipid kinases that are implicated in signal transduction. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. It forms a heterodimer of a catalytic subunit (PI3 Kinase catalytic subunit gamma/p120) with the regulatory (PIK3R5/p101) subunit. PI3KR5 is a receptor-regulated class I phosphoinositide 3-kinases (PI3Ks) phosphorylate the membrane lipid phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns(3,4,5)P3, which in turn recruits and activates cytosolic effectors involved in proliferation, survival, or chemotaxis. PIK3R5 is a PI3K regulatory subunit.
  • 細胞内局在PIK3R5: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein.

Recombinant human PIK3CG + PIK3R5 protein (ab68181) 使用論文

ab68181 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"