製品の概要

  • 製品名Recombinant Human PIAS3 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9Y6X2
    • 生物種Human
    • 分子量27 kDa
    • 領域274 to 521

特性

Our Abpromise guarantee covers the use of ab125996 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C.

    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride

  • 再構成Reconstitute with water to desired concentration.

関連情報

  • 別名
    • E3 SUMO protein ligase PIAS 3
    • E3 SUMO protein ligase PIAS3
    • E3 SUMO-protein ligase PIAS3
    • FLJ14651
    • OTTHUMP00000015586
    • OTTHUMP00000015587
    • PIAS 3
    • Pias3
    • PIAS3 protein
    • PIAS3_HUMAN
    • Protein inhibitor of activated STAT 3
    • Protein inhibitor of activated STAT protein 3
    • Protein inhibitor of activated STAT3
    • Zinc finger MIZ type containing 5
    • ZMIZ 5
    • ZMIZ5
    see all
  • 機能Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
  • 組織特異性Widely expressed.
  • パスウェイProtein modification; protein sumoylation.
  • 配列類似性Belongs to the PIAS family.
    Contains 1 PINIT domain.
    Contains 1 SAP domain.
    Contains 1 SP-RING-type zinc finger.
  • ドメインThe PINIT domain of PIAS3 is required for STAT3-PIAS3 interaction and for transloaction to the nucleus.
    The LXXLL motif is a transcriptional coregulator signature.
  • 翻訳後修飾Sumoylated.
  • 細胞内局在Cytoplasm. Nucleus. Nucleus speckle. Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules.
  • Information by UniProt

Recombinant Human PIAS3 protein (ab125996) 使用論文

ab125996 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab125996.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"