Recombinant Human Phospholipase A2 protein (ab112338)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Wheat germ
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFI STTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDE TLGTATFTVS
    • 分子量
      38 kDa including tags
    • 領域
      1 to 110
    • タグ
      GST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab112338 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    ELISA

    Western blot

  • 製品の状態
    Liquid
  • 備考
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Calcium dependent phospholipid binding protein
    • CPLA 2
    • cPLA2
    • cPLA2 alpha
    • Cytosolic phospholipase A2
    • Cytosolic phospholipase A2 group IVA
    • Lysophospholipase
    • MGC126350
    • PA24A_HUMAN
    • Phosphatidylcholine 2 acylhydrolase
    • Phosphatidylcholine 2-acylhydrolase
    • Phospholipase A2 group 4 A
    • Phospholipase A2 group IVA
    • Phospholipase A2 group IVA (cytosolic calcium dependent)
    • PhospholipaseA2
    • PLA2G4
    • pla2g4a
    see all
  • 機能
    Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
  • 組織特異性
    Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
  • 配列類似性
    Contains 1 C2 domain.
    Contains 1 PLA2c domain.
  • ドメイン
    The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+).
  • 翻訳後修飾
    Activated by phosphorylation at both Ser-505 and Ser-727.
  • 細胞内局在
    Cytoplasm. Cytoplasmic vesicle. Translocates to membrane vesicles in a calcium-dependent fashion.
  • Information by UniProt

画像

  • ab112338 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

参考文献

ab112338 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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