Recombinant Human Phospholamban protein (ab114227)

製品の概要

  • 製品名Recombinant Human Phospholamban protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号P26678
    • 生物種Human
    • 配列MEKVQYLTRSAIRRASTIEMPQQARQKLQN
    • 分子量29 kDa including tags
    • 領域1 to 30

特性

Our Abpromise guarantee covers the use of ab114227 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

関連情報

  • 別名
    • Cardiac phospholamban
    • CMD1P
    • CMH18
    • PLB
    • Pln
    • PPLA_HUMAN
    see all
  • 機能Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.
  • 組織特異性Heart muscle (at protein level).
  • 関連疾患Cardiomyopathy, dilated 1P
    Cardiomyopathy, familial hypertrophic 18
  • 配列類似性Belongs to the phospholamban family.
  • 翻訳後修飾Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.
  • 細胞内局在Endoplasmic reticulum membrane. Sarcoplasmic reticulum membrane. Mitochondrion membrane. Membrane. Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK a the sarcoplasmic reticulum (PubMed:15598648).
  • Information by UniProt

Recombinant Human Phospholamban protein 画像

  • ab114227 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human Phospholamban protein (ab114227) 使用論文

ab114227 has not yet been referenced specifically in any publications.

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