Recombinant Human PHLPP2 protein (ab125556)

製品の概要

  • 製品名Recombinant Human PHLPP2 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q6ZVD8
    • 生物種Human
    • 分子量56 kDa including tags
    • 領域766 to 1043

特性

Our Abpromise guarantee covers the use of ab125556 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Western blot

    SDS-PAGE

  • 精製度> 95 % Densitometry.
    ab125556 is >95% pure.
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

関連情報

  • 別名
    • KIAA0931
    • PH domain and leucine rich repeat protein phosphatase 2
    • PH domain leucine rich repeat protein phosphatase like
    • PH domain leucine-rich repeat-containing protein phosphatase 2
    • PH domain leucine-rich repeat-containing protein phosphatase-like
    • PHLP2_HUMAN
    • PHLPP like
    • PHLPP-like
    • Phlpp2
    • PHLPPL
    see all
  • 機能Protein phosphatase that mediates dephosphorylation of 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Inhibits cancer cell proliferation and may act as a tumor suppressor.
  • 組織特異性In colorectal cancer tissue, expression is highest in the surface epithelium of normal colonic mucosa adjacent to the cancer tissue but is largely excluded from the crypt bases. Expression is lost or significantly decreased in 80% of tested tumors (at protein level).
  • 配列類似性Contains 22 LRR (leucine-rich) repeats.
    Contains 1 PH domain.
    Contains 1 PP2C-like domain.
  • 細胞内局在Cytoplasm. Membrane. Nucleus. In colorectal cancer tissue, expression is concentrated in the cytoplasm and nucleus.
  • Information by UniProt

Recombinant Human PHLPP2 protein 画像

  • SDS PAGE analysis of ab125556 (PHLPP2 protein).

Recombinant Human PHLPP2 protein (ab125556) 使用論文

ab125556 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"