製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKV IDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFF FLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRD LKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSM NEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFG SPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFS PRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAY AFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEDY
    • 分子量
      70 kDa including tags
    • 領域
      1 to 387

関連製品

特性

Our Abpromise guarantee covers the use of ab101715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The specific activity of PHKG1 was determined to be 29 nmol/min/mg.
  • アプリケーション

    SDS-PAGE

    Functional Studies

  • 精製度
    > 75 % SDS-PAGE.

  • 製品の状態
    Liquid
  • 備考

    ab204885 (ZIP Kinase peptide substrate) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • PHK gamma M
    • PHK-gamma-M
    • Phkg
    • PHKG1
    • PHKG1_HUMAN
    • PHKIN01
    • Phosphorylase b kinase gamma catalytic chain
    • Phosphorylase b kinase gamma catalytic chain skeletal muscle/heart isoform
    • phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform
    • phosphorylase kinase gamma
    • phosphorylase kinase subunit gamma 1
    • Phosphorylase kinase subunit gamma-1
    • phosphorylase kinase, gamma 1 (muscle)
    • Phosphorylase kinase, muscle, gamma-1
    • Serine/threonine-protein kinase PHKG1
    • skeletal muscle/heart isoform
    see all
  • 機能
    Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.
  • 配列類似性
    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • ドメイン
    The two calmodulin-binding domains appear to act in concert to bind a single molecule of calmodulin and are pseudosubstrate/autoinhibitory domains.
  • Information by UniProt

画像

  • The putity of ab101715 was determined to be 75% by densitometry.

    Approximate MWt: 70kDa
  • The specific activity of ab101715 was determined to be 29 nmol/min/mg.

参考文献

ab101715 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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