The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab123178 is purified using conventional chromatography.
BRENDA (Enzyme Commission number) EC=184.108.40.206; EC=220.127.116.11; EC=18.104.22.168.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Information available upon request.
BPG dependent PGAM 2
BPG-dependent PGAM 2
Muscle specific phosphoglycerate mutase
Muscle-specific phosphoglycerate mutase
Phosphoglycerate mutase 2
phosphoglycerate mutase 2 (muscle)
Phosphoglycerate mutase isozyme M
Interconversion of 3- and 2-phosphoglycerate with 2,3-bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 22.214.171.124 (synthase) and EC 126.96.36.199 (phosphatase), but with a reduced activity.
In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues.
Defects in PGAM2 are the cause of glycogen storage disease type 10 (GSD10) [MIM:261670]. A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps and excercise intolerance.
Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.