Recombinant human Peroxiredoxin 1 protein (ab74172)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human
    • 配列
      MGSSHHHHHH SSGLVPRGSH MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS DRAEEFKKLN CQVIGASVDS HFCHLAWVNT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK ADEGISFRGL FIIDDKGILR QITVNDLPVG RSVDETLRLV QAFQFTDKHG EVCPAGWKPG SDTIKPDVQK SKEYFSKQK

特性

Our Abpromise guarantee covers the use of ab74172 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    Specific activity: approximately 600-670 pmole/min/µg. Enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX1 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25 C for 1 minute.
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度
    > 90 % SDS-PAGE.
    ab74172 is purified by conventional chromatography techniques.
  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • Heme binding 23 kDa protein
    • MSP23
    • Natural killer cell-enhancing factor A
    • NKEF A
    • NKEF-A
    • NKEFA
    • OSF3
    • Osteoblast specific factor 3
    • PAG
    • Paga
    • PAGB
    • Peroxiredoxin-1
    • PRDX1
    • PRDX1_HUMAN
    • Proliferation associated gene A
    • Proliferation-associated gene protein
    • PRX1
    • PrxI
    • TDPX2
    • Thioredoxin peroxidase 2
    • Thioredoxin-dependent peroxide reductase 2
    see all
  • 機能
    Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
  • 配列類似性
    Belongs to the ahpC/TSA family.
    Contains 1 thioredoxin domain.
  • 翻訳後修飾
    Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.
  • 細胞内局在
    Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt

画像

  • ab74172, detecting Peroxiredoxin 1 protein (His tag) at 24 kDa by SDS-PAGE

参考文献

ab74172 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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