製品の概要

  • 製品名Recombinant Human PER2 protein
  • タンパク質長Protein fragment

製品の詳細

  • 由来Recombinant
  • 由来Wheat germ
  • アミノ酸配列
    • アクセッション番号O15055
    • 生物種Human
    • 配列MNGYAEFPPSPSNPTKEPVEPQPSQVPLQEDVDMSSGSSGHETNENCSTG RDSQGSDCDDSGKELGMLVEPPDARQSPDTFSLMMAKSEHNPSTSGCSSD
    • 分子量37 kDa including tags
    • 領域1 to 100

特性

Our Abpromise guarantee covers the use of ab112382 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性Useful for Antibody Production and Protein Array
  • アプリケーション

    ELISA

    SDS-PAGE

    Western blot

  • 製品の状態Liquid
  • 備考ab112382 is best used within three months from the date of receiptUseful for Antibody Production and Protein Array
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

関連情報

  • 別名
    • Circadian clock protein PERIOD 2
    • FASPS
    • FASPS1
    • hPER 2
    • hPER2
    • KIAA0347
    • OTTHUMP00000164476
    • PER 2
    • PER2
    • PER2_HUMAN
    • Period 2
    • Period 2 isoform 1
    • Period circadian clock 2
    • Period circadian protein 2
    • Period circadian protein homolog 2
    • Period homolog 2
    • Period homolog 2 (Drosophila)
    • Period, Drosophila, homolog of, 2
    • Period2
    see all
  • 機能Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK
    NPAS2-BMAL1
    BMAL2-induced transactivation.
  • 組織特異性Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low level in lung.
  • 関連疾患Defects in PER2 are a cause of familial advanced sleep-phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms.
  • 配列類似性Contains 1 PAC (PAS-associated C-terminal) domain.
    Contains 2 PAS (PER-ARNT-SIM) domains.
  • 翻訳後修飾Phosphorylated by CSNK1E and CSNK1D. Phosphorylation results in PER2 protein degradation.
  • 細胞内局在Nucleus. Cytoplasm. Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.
  • Information by UniProt

Recombinant Human PER2 protein 画像

  • ab112382 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human PER2 protein (ab112382) 使用論文

ab112382 has not yet been referenced specifically in any publications.

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