The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab123832 is purified by proprietary chromatographic techniques.
備考Storage: Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time, but remains stable until the expiry date when stored at -20°C.
再構成Add deionized water to a working concentration of 0.5 mg/ml and let the lyophilized pellet dissolve completely.
Cell proliferation-inducing gene 35 protein
Pigment epithelium derived factor
Pigment epithelium-derived factor
Proliferation inducing protein 35
serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Serpin family F member 1
Serpin peptidase inhibitor clade F member 1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
機能Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
組織特異性Retinal pigment epithelial cells and blood plasma.
配列類似性Belongs to the serpin family.
発生段階Expressed in quiescent cells.
ドメインThe N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.
翻訳後修飾The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity. N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
細胞内局在Secreted. Melanosome. Enriched in stage I melanosomes.