製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      45 kDa
    • 領域
      20 to 418

特性

Our Abpromise guarantee covers the use of ab123756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

    HPLC

  • 精製度
    > 95 % SDS-PAGE.
    Purity is greater than 95% as determined by HPLC and SDS-PAGE. Endotoxin level is <0.1 ng/µg of human PEDF.
  • 製品の状態
    Lyophilised
  • 備考
    Endotoxin Level: <0.1 ng/µg.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    pH: 7.40
    Constituents: PBS, 0.88% Sodium chloride

  • 再構成
    Centrifuge the vial prior to opening. Reconstitute in sterile dH2O to a concentration of 0.1 -1mg/ml and let the lyophilized pellet dissolve completely. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

関連情報

  • 別名
    • Cell proliferation-inducing gene 35 protein
    • EPC 1
    • EPC-1
    • EPC1
    • OI12
    • OI6
    • PEDF
    • PEDF_HUMAN
    • PIG 35
    • PIG35
    • Pigment epithelium derived factor
    • Pigment epithelium-derived factor
    • Proliferation inducing protein 35
    • serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
    • Serpin F1
    • Serpin family F member 1
    • Serpin peptidase inhibitor clade F member 1
    • serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
    • SERPINF 1
    • Serpinf1
    see all
  • 機能
    Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
  • 組織特異性
    Retinal pigment epithelial cells and blood plasma.
  • 配列類似性
    Belongs to the serpin family.
  • 発生段階
    Expressed in quiescent cells.
  • ドメイン
    The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity.
  • 翻訳後修飾
    The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.
    N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
  • 細胞内局在
    Secreted. Melanosome. Enriched in stage I melanosomes.
  • Information by UniProt

参考文献

ab123756 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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