製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MAEYGTLLQD LTNNITLEDL LKSACKED IPSEKSEEIT TGSAWFSFLE HNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EDELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
    • 分子量
      15 kDa
    • 領域
      1 to 130

特性

Our Abpromise guarantee covers the use of ab117660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度
    > 90 % SDS-PAGE.

  • 製品の状態
    Liquid
  • 備考
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.

    pH: 7.50
    Constituents: 0.32% Tris HCl, 0.02% DTT, 10% Glycerol

関連情報

  • 別名
    • 15 kDa phosphoprotein enriched in astrocytes
    • Astrocytic phosphoprotein PEA 15
    • Astrocytic phosphoprotein PEA-15
    • Astrocytic phosphoprotein PEA15
    • HMAT 1
    • HMAT1
    • Homolog of mouse MAT 1 oncogene
    • Homolog of mouse MAT1 oncogene
    • HUMMAT 1H
    • HUMMAT1H
    • MAT 1
    • MAT 1H
    • MAT1
    • MAT1H
    • PEA 15
    • Pea15
    • PEA15 protein
    • PEA15_HUMAN
    • PED
    • Phosphoprotein enriched in astrocytes 15
    • Phosphoprotein enriched in astrocytes 15kD
    • Phosphoprotein enriched in diabetes
    see all
  • 機能
    Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
  • 組織特異性
    Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.
  • 配列類似性
    Contains 1 DED (death effector) domain.
  • 翻訳後修飾
    Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.
  • 細胞内局在
    Cytoplasm. Associated with microtubules.
  • Information by UniProt

参考文献

ab117660 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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