The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
備考Protein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
C terminal linking and modulating protein
CFTR associated protein of 70 kDa
CFTR associated protein, 70-KD
CFTR-associated protein of 70 kDa
Dietary Pi-regulated RNA-1
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
Na(+)/H(+) exchanger regulatory factor 3
Na/Pi cotransporter C-terminal-associated protein
Na/Pi cotransporter C-terminal-associated protein 1
PDZ domain containing 1
PDZ domain containing protein 1
PDZ domain-containing protein 1
Sodium hydrogen exchanger regulatory factor 3
Sodium-hydrogen exchanger regulatory factor 3
機能A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
組織特異性Expression is limited to epithelial cells. Expressed in the kidney (brush border of proximal tubule), pancreas, liver, and small intestine. Expressed at a lower level in the adrenal cortex, testis and stomach. Overexpressed in breast, renal and lung carcinomas.
配列類似性Belongs to the NHER family. Contains 4 PDZ (DHR) domains.
ドメインThe PDZ 2 and 3 domains seem to be involved in the interaction with SLC26A3. Interaction with the C-terminus of CFTR could be mediated through independent binding of PDZ 1, 3 and 4 domains. The PDZ 1 and 3 domains seem to be involved in the interaction with SLCO1A1. The PDZ 1 domain interacts with BCR.
細胞内局在Cytoplasm. Membrane. Associated with peripheral membranes. Localizes to the apical compartment of proximal tubular cells and to sinusoidal liver membranes.