Recombinant Human PDP1 protein (ab110357)

製品の概要

  • 製品名
    Recombinant Human PDP1 protein
  • タンパク質長
    Full length protein

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 領域
      72 to 537

特性

Our Abpromise guarantee covers the use of ab110357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Functional Studies

    Sandwich ELISA

  • 精製度
    > 90 % Purified via His tag.

  • 製品の状態
    Liquid
  • 備考

    The pyruvate dehydrogenase complex (PDH) is at the center of aerobic carbohydrate metabolism. It is localized in the matrix space of mitochondria where it catalyzes the irreversible oxidative decarboxylation of pyruvate entering the organelle to produce acetyl-CoA, NADH and CO2. PDH is a complex of three different enzymes that channel substrate and product. These are pyruvate dehydrogenase (E1), dihydrolipoamide transacetylase (E2) and dihydrolipoamide dehydrogenase (E3). PDH deficiencies, diabetes, starvation, sepsis, and possibly Alzheimer's disease have been linked to altered PDH functioning.

    Product was previously marketed under the MitoSciences sub-brand.

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.14% Sodium phosphate, 1.46% Sodium chloride, 30% Glycerol, 0.08% DTT, 0.02% EDTA, 0.05% Triton-X-100

関連情報

  • 別名
    • [Pyruvate dehydrogenase [acetyl transferring]] phosphatase 1, mitochondrial
    • [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1
    • FLJ32517
    • Gm1024
    • MGC119646
    • mitochondrial
    • PDH
    • PDP
    • PDP 1
    • Pdp1
    • PDP1_HUMAN
    • PDPC
    • PDPC 1
    • PPM2C
    • Protein phosphatase 2C
    • protein phosphatase 2C, magnesium dependent, catalytic subunit
    • Pyruvate dehydrogenase (Lipoamide) phosphatase phosphatase
    • Pyruvate dehydrogenase phosphatase catalytic subunit 1
    • Pyruvate dehydrogenase phosphatase, catalytic subunit 1
    • RP23 203A12.1
    see all
  • 機能
    Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
  • 関連疾患
    Defects in PDP1 are the cause of pyruvate dehydrogenase phosphatase deficiency (PDP deficiency) [MIM:608782]. PDP deficiency results in lactic acidosis leading to neurological dysfunction.
  • 配列類似性
    Belongs to the PP2C family.
  • 細胞内局在
    Mitochondrion matrix.
  • Information by UniProt

参考文献

ab110357 has not yet been referenced specifically in any publications.

レビューと Q&A

We advise use of PBS for homogenization of muscle tissue. We have not tested the use of this kit with fat tissue. If you have a favorite homogenization buffer, we would advice to prepare the homogenates of both tissues in both buffers in parallel , run...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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