製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 分子量
      70 kDa including tags
    • 領域
      1 to 407

特性

Our Abpromise guarantee covers the use of ab125592 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The specific activity of ab125592 was determined to be 7.5 nmol/min/mg.
  • アプリケーション

    Western blot

    Functional Studies

    SDS-PAGE

  • 製品の状態
    Liquid
  • 備考

    ab125602 (Human Pyruvate Dehydrogenase E1-alpha subunit full length protein) can be utilized as a substrate for assessing Kinase activity

  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2
    • mitochondrial
    • PDHK2
    • PDK2
    • PDK2_HUMAN
    • Pyruvate dehydrogenase kinase isoform 2
    • Pyruvate dehydrogenase kinase, isozyme 2
    • Pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial
    see all
  • 機能
    Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.
  • 組織特異性
    Expressed in many tissues, with the highest level in heart and skeletal muscle, intermediate levels in brain, kidney, pancreas and liver, and low levels in placenta and lung.
  • 配列類似性
    Belongs to the PDK/BCKDK protein kinase family.
    Contains 1 histidine kinase domain.
  • 細胞内局在
    Mitochondrion matrix.
  • Information by UniProt

画像

  • SDS Page analysis of ab125592
  • The specific activity of ab125592 was determined to be 7.5 nmol/min/mg

参考文献

ab125592 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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