製品の概要

法規制情報

製品の詳細

  • 由来
    Recombinant
  • 由来
    Baculovirus infected Sf9 cells
  • アミノ酸配列
    • アクセッション番号
    • 生物種
      Human
    • 配列
      MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSSNSL NILDDDYNGQ AKCMLEKVGN WNFDIFLFDR LTNGNSLVSL TFHLFSLHGL IEYFHLDMMK LRRFLVMIQE DYHSQNPYHN AVHAADVTQA MHCYLKEPKL ANSVTPWDIL LSLIAAATHD LDHPGVNQPF LIKTNHYLAT LYKNTSVLEN HHWRSAVGLL RESGLFSHLP LESRQQMETQ IGALILATDI SRQNEYLSLF RSHLDRGDLC LEDTRHRHLV LQMALKCADI CNPCRTWELS KQWSEKVTEE FFHQGDIEKK YHLGVSPLCD RHTESIANIQ IGFMTYLVEP LFTEWARFSN TRLSQTMLGH VGLNKASWKG LQREQSSSED TDAAFELNSQ LLPQENRLS
    • 分子量
      64 kDa including tags
    • 領域
      104 to 456
    • タグ
      GST tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab125786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    The specific activity of ab125786 was determined to be 166 nmol/min/mg.
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度
    > 85 % Densitometry.

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.002% PMSF, 0.4% DTT, 0.79% Tris HCl, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 5''-cyclic phosphodiesterase 7A
    • HCP 1
    • HCP1
    • High affinity cAMP specific 3'5' cyclic phosphodiesterase 7A
    • High affinity cAMP-specific 3''
    • P2A
    • PDE 7
    • PDE 7A
    • PDE1/PDE2 yeast human complement of
    • PDE7
    • PDE71
    • PDE7A
    • PDE7A_HUMAN
    • Phosphodiesterase 7A
    • Phosphodiesterase isozyme 7
    • Phosphodiesterase7A
    • Rolipram insensitive phosphodiesterase type 7
    • TM 22
    • TM22
    see all
  • 機能
    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
  • 組織特異性
    PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.
  • パスウェイ
    Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
  • 配列類似性
    Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.
  • 発生段階
    Developmentally regulated. PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development. It persists strongly only in adult skeletal muscle.
  • ドメイン
    Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain.
  • 細胞内局在
    Cytoplasm > cytosol. PDE7A1 (57 kDa) is located mostly to soluble cellular fractions and Cytoplasm. PDE7A2 (50 kDa) is located to particulate cellular fractions.
  • Information by UniProt

Recombinant human PDE7A protein 画像

  • SDS-PAGE analysis of ab125786.
  • Sample assay showing the specific activity of ab125786 to be 166 nmol/min/mg.

Recombinant human PDE7A protein (ab125786) 使用論文

ab125786 has not yet been referenced specifically in any publications.

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