Recombinant human PDE6 alpha protein (ab101586)

製品の概要

法規制情報

製品の詳細

  • 由来Recombinant
  • 由来Baculovirus
  • アミノ酸配列
    • アクセッション番号P16499
    • 生物種Human
    • 分子量120 kDa including tags
    • 領域31 to 857

特性

Our Abpromise guarantee covers the use of ab101586 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性the specific activity of PDE6 alpha was determined to be 38 nmol/min/mg
  • アプリケーション

    Functional Studies

    SDS-PAGE

  • 精製度> 70 % SDS-PAGE.
    The purity was determined to be >70% by densitometry
  • 製品の状態Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

関連情報

  • 別名
    • 5''-cyclic phosphodiesterase subunit alpha
    • CGPR A
    • GMP PDE alpha
    • GMP-PDE alpha
    • PDE 6 alpha
    • PDE 6A
    • PDE V B1
    • PDE V-B1
    • PDE6A
    • PDE6A_HUMAN
    • PDEA
    • Phosphodiesterase 6 alpha
    • Phosphodiesterase 6A alpha subunit
    • Phosphodiesterase 6A cGMP specific rod alpha
    • Retinal Rod Photoreceptor cGMP Phosphodiesterase alpha
    • Rod cGMP specific 3' 5' cyclic phosphodiesterase alpha subunit
    • Rod cGMP-specific 3''
    see all
  • 機能This protein participates in processes of transmission and amplification of the visual signal.
  • 関連疾患Defects in PDE6A are the cause of retinitis pigmentosa type 43 (RP43) [MIM:613810]. RP43 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 配列類似性Belongs to the cyclic nucleotide phosphodiesterase family.
    Contains 2 GAF domains.
  • 細胞内局在Cell membrane.
  • Information by UniProt

Recombinant human PDE6 alpha protein 画像

  • SDS Page analysis of ab101586
  • Specific activity of ab101586

Recombinant human PDE6 alpha protein (ab101586) 使用論文

ab101586 has not yet been referenced specifically in any publications.

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