Recombinant Human PDCD10 protein (ab113198)

製品の概要

製品の詳細

  • 由来Recombinant
  • 由来Escherichia coli
  • アミノ酸配列
    • アクセッション番号Q9BUL8
    • 生物種Human
    • 配列MGSSHHHHHHSSGLVPRGSMRMTMEEMKNEAETTSMVSMPLYAVMYPVFN ELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLL RMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTI KDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTY FKDGKAINVFVSANRLIHQTNLILQTFKTVA
    • 分子量27 kDa including tags
    • 領域1 to 212
    • タグHis tag N-Terminus

特性

Our Abpromise guarantee covers the use of ab113198 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    SDS-PAGE

  • 精製度> 95 % SDS-PAGE.
    Purity is >95%, by SDS-PAGE and silver stain.
  • 製品の状態Lyophilised
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

  • 再構成The lyophilized ab113198 should be reconstituted in water or PBS to a concentration not lower than 50 µg/ml.

関連情報

  • 別名
    • Apoptosis related protein 15
    • CCM3
    • Cerebral cavernous malformations 3 protein
    • MGC1212
    • MGC24477
    • PDC10_HUMAN
    • PDCD 10
    • PDCD10
    • Programmed cell death 10
    • Programmed cell death protein 10
    • TF 1 cell apoptosis related protein 15
    • TF-1 cell apoptosis-related protein 15
    • TFAR15
    see all
  • 機能Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development.
  • 組織特異性Ubiquitous.
  • 関連疾患Defects in PDCD10 are the cause of cerebral cavernous malformations type 3 (CCM3) [MIM:603285]. Cerebral cavernous malformations (CCMs) are congenital vascular anomalies of the central nervous system that can result in hemorrhagic stroke, seizures, recurrent headaches, and focal neurologic deficits. CCMs have an incidence of 0.1%-0.5% in the general population and usually present clinically during the 3rd to 5th decade of life. The lesions are characterized by grossly enlarged blood vessels consisting of a single layer of endothelium and without any intervening neural tissue, ranging in diameter from a few millimeters to several centimeters.
  • 配列類似性Belongs to the PDCD10 family.
  • 細胞内局在Cytoplasm. Golgi apparatus membrane. Cell membrane. Partially co-localizes with endogenous PXN at the leading edges of migrating cells.
  • Information by UniProt

Recombinant Human PDCD10 protein 画像

  • SDS-PAGE of recombinant CCM3 (ab113198). The sample was loaded in 15% SDS-polyacrylamide gel under reducing conditions and stained with silver stain.

Recombinant Human PDCD10 protein (ab113198) 使用論文

ab113198 has not yet been referenced specifically in any publications.

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