Recombinant Human PC4 (mutated S13 + S15 + S17 + S19) protein (ab81957)

製品の概要

製品の詳細

  • 由来
    Recombinant
  • 由来
    Escherichia coli
  • アミノ酸配列
    • 生物種
      Human
    • 修飾
      mutated S

特性

Our Abpromise guarantee covers the use of ab81957 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生理活性
    1 unit equals 1 nanogram of purified protein.
  • アプリケーション

    SDS-PAGE

    Functional Studies

    EMSA

  • 精製度
    > 95 % SDS-PAGE.
    ab81957 is purified by conventional chromatography.
  • 製品の状態
    Liquid
  • 備考


    Wild-type PC4, but not the kinase inhibitory-deficient mutant of PC4 (serine mutations), represses specific transcription in vivo.

    1 unit equals 1 nanogram of purified protein.
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 20mM Tris HCl, 100mM Potassium chloride, 1mM DTT, 0.2mM EDTA, pH 8.0

関連情報

  • 別名
    • Activated RNA polymerase II transcriptional coactivator p15
    • Interferon related developmental regulator 1
    • MGC102747
    • p14
    • P15
    • PC4
    • PC4 LSB
    • Positive cofactor 4
    • RPO2TC1
    • Sub1
    • SUB1 homolog
    • TCP4_HUMAN
    see all
  • 機能
    General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
  • 配列類似性
    Belongs to the transcriptional coactivator PC4 family.
  • 翻訳後修飾
    Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region.
  • 細胞内局在
    Nucleus.
  • Information by UniProt

参考文献

ab81957 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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